Microfluidics for in vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans

@article{Chronis2007MicrofluidicsFI,
  title={Microfluidics for in vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans},
  author={Nikos Chronis and Manuel Zimmer and Cornelia I Bargmann},
  journal={Nature Methods},
  year={2007},
  volume={4},
  pages={727-731}
}
The nematode C. elegans is an excellent model organism for studying behavior at the neuronal level. Because of the organism's small size, it is challenging to deliver stimuli to C. elegans and monitor neuronal activity in a controlled environment. To address this problem, we developed two microfluidic chips, the 'behavior' chip and the 'olfactory' chip for imaging of neuronal and behavioral responses in C. elegans. We used the behavior chip to correlate the activity of AVA command interneurons… CONTINUE READING
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