Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays.

@article{Saliba2010MicrofluidicSA,
  title={Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays.},
  author={Antoine-Emmanuel Saliba and Laure Saias and Eleni Psychari and Nicolas Minc and Damien Simon and François-Cl{\'e}ment Bidard and Claire Mathiot and J -Y. Pierga and Vincent Fraisier and Jean Salamero and V{\'e}ronique Saada and Françoise Farace and Philippe Vielh and Laurent Malaquin and Jean-Louis Viovy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 33},
  pages={14524-9}
}
We propose a unique method for cell sorting, "Ephesia," using columns of biofunctionalized superparamagnetic beads self-assembled in a microfluidic channel onto an array of magnetic traps prepared by microcontact printing. It combines the advantages of microfluidic cell sorting, notably the application of a well controlled, flow-activated interaction between cells and beads, and those of immunomagnetic sorting, notably the use of batch-prepared, well characterized antibody-bearing beads. On… CONTINUE READING

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