Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells.

@article{Faley2009MicrofluidicSC,
  title={Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells.},
  author={Shannon L Faley and Mhairi Copland and Donald Wlodkowic and Walter Kolch and Kevin T. Seale and John P. Wikswo and Jonathan M. Cooper},
  journal={Lab on a chip},
  year={2009},
  volume={9 18},
  pages={
          2659-64
        }
}
Stem cells hold great promise as a means of treating otherwise incurable, degenerative diseases due to their ability both to self-renew and differentiate. However, stem cell damage can also play a role in the disease with the formation of solid tumors and leukaemias such as chronic myeloid leukaemia (CML), a hematopoietic stem cell (HSC) disorder. Despite recent medical advances, CML remains incurable by drug therapy. Understanding the mechanisms which govern chemoresistance of individual stem… CONTINUE READING

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