Microfluidic single-cell array cytometry for the analysis of tumor apoptosis.

@article{Wlodkowic2009MicrofluidicSA,
  title={Microfluidic single-cell array cytometry for the analysis of tumor apoptosis.},
  author={Donald Wlodkowic and Shannon L Faley and Michele Zagnoni and John P. Wikswo and Jonathan M. Cooper},
  journal={Analytical chemistry},
  year={2009},
  volume={81 13},
  pages={
          5517-23
        }
}
Limitations imposed by conventional analytical technologies for cell biology, such as flow cytometry or microplate imaging, are often prohibitive for the kinetic analysis of single-cell responses to therapeutic compounds. In this paper, we describe the application of a microfluidic array to the real-time screening of anticancer drugs against arrays of single cells. The microfluidic platform comprises an array of micromechanical traps, designed to passively corral individual nonadherent cells… CONTINUE READING

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