Microfluidic shear stress-regulated surfactant secretion in alveolar epithelial type II cells in vitro.

Abstract

We investigated the role of flow-induced shear stress on the mechanisms regulating surfactant secretion in type II alveolar epithelial cells (ATII) using microfluidic models. Following flow stimulation spanning a range of wall shear stress (WSS) magnitudes, monolayers of ATII (MLE-12 and A549) cells were examined for surfactant secretion by evaluating… (More)
DOI: 10.1152/ajplung.00106.2013

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