Microfluidic shear devices for quantitative analysis of cell adhesion.

  title={Microfluidic shear devices for quantitative analysis of cell adhesion.},
  author={Hang Lu and Lily Y Koo and Wechung Maria Wang and Douglas A. Lauffenburger and Linda G Griffith and Klavs F Jensen},
  journal={Analytical chemistry},
  volume={76 18},
We describe the design, construction, and characterization of microfluidic devices for studying cell adhesion and cell mechanics. The method offers multiple advantages over previous approaches, including a wide range of distractive forces, high-throughput performance, simplicity in experimental setup and control, and potential for integration with other microanalytic modules. By manipulating the geometry and surface chemistry of the microdevices, we are able to vary the shear force and the… CONTINUE READING
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