Microfluidic organs-on-chips

  title={Microfluidic organs-on-chips},
  author={Sangeeta N. Bhatia and Donald E. Ingber},
  journal={Nature Biotechnology},
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing methods that contains continuously perfused chambers inhabited by living cells arranged to simulate tissue- and organ-level physiology. By recapitulating the multicellular architectures, tissue-tissue interfaces, physicochemical microenvironments and vascular perfusion of the body, these devices produce levels of tissue and organ functionality not possible with conventional 2D or 3D culture systems… CONTINUE READING
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Evaluation of a liver microfluidic biochip to predict in vivo clearances of seven drugs in rats

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