Microfluidic on-demand droplet merging using surface acoustic waves.

@article{Sesen2014MicrofluidicOD,
  title={Microfluidic on-demand droplet merging using surface acoustic waves.},
  author={Muhsincan Sesen and Tuncay Alan and Adrian Neild},
  journal={Lab on a chip},
  year={2014},
  volume={14 17},
  pages={
          3325-33
        }
}
Individual droplets can be isolated within microfluidic systems by use of an immiscible carrier layer. This type of two phase systems, often termed "digital microfluidics", find wide ranging applications in chemical synthesis and analysis. To conduct on-chip biochemical analysis, a key step is to be able to merge droplets selectively in order to initiate the required reactions. In this paper, a novel microfluidic chip integrating interdigital transducers is designed to merge multiple droplets… 
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References

SHOWING 1-10 OF 74 REFERENCES
Pillar-induced droplet merging in microfluidic circuits.
TLDR
It is shown that the merging of droplet interfaces occurs within both compressing and the decompressing regimes, and the number of droplets that can be merged at any time is also dependent on the mass flow rate and volume ratio between the droplets and the merging chamber.
Surface acoustic waves for on-demand production of picoliter droplets and particle encapsulation.
TLDR
A novel method to produce individual picoliter-scale droplets on-demand using surface acoustic waves (SAW) is presented, able to pre-concentrate particles simultaneously with droplet production, meaning that particles and cells, even if in a dilute mixture, can be easily encapsulated.
Surface acoustic wave microfluidics.
TLDR
The theory underpinning SAWs and their interactions with particles and the contacting fluids in which they are suspended are discussed, and the SAW-enabled microfluidic devices demonstrated to date are reviewed.
Electric control of droplets in microfluidic devices.
TLDR
This work presents a platform technology based on charged droplets and electric fields that enables electrically addressable droplets generation, highly efficient droplet coalescence, precision droplet breaking and recharging, and controllable droplet sorting and is an essential enabling technology for a high-throughput droplet microfluidic reactor.
Selective particle and cell clustering at air–liquid interfaces within ultrasonic microfluidic systems
In this study, we demonstrate particle and cell clustering in distinct patterns on the free surface of microfluidic volumes. Employing ultrasonic actuation, submersed microparticles are forced to two…
Design of microfluidic channel geometries for the control of droplet volume, chemical concentration, and sorting.
Passive microfluidic channel geometries for control of droplet fission, fusion and sorting are designed, fabricated, and tested. In droplet fission, the inlet width of the bifurcating junction is…
Continuous particle separation in a microfluidic channel via standing surface acoustic waves (SSAW).
TLDR
The particle separation method presented here is simple and versatile, capable of separating virtually all kinds of particles (regardless of charge/polarization or optical properties) with high separation efficiency and low power consumption.
High-throughput micromixers based on acoustic streaming induced by surface acoustic wave
Flow characteristics in microfluidic devices is naturally laminar due to the small channel dimensions. Mixing based on molecular diffusion is generally poor. In this article, we report the…
Microfluidics for miniaturized laboratories on a chip.
  • T. Franke, A. Wixforth
  • Chemistry
    Chemphyschem : a European journal of chemical physics and physical chemistry
  • 2008
TLDR
This Review surveys some of the approaches and techniques to handle minute amounts of fluid volumes in microfluidic systems with special focus on surface acoustic wave driven fluidics, a technique developed in the laboratory.
Droplet coalescence by geometrically mediated flow in microfluidic channels
Microfluidic flow is geometrically mediated at a trifurcating junction allowing periodically formed, equally spaced out emulsion droplets to redistribute and fuse consistently. This is achieved by…
...
1
2
3
4
5
...