Microfluidic investigation reveals distinct roles for actin cytoskeleton and myosin II activity in capillary leukocyte trafficking.

@article{Gabriele2009MicrofluidicIR,
  title={Microfluidic investigation reveals distinct roles for actin cytoskeleton and myosin II activity in capillary leukocyte trafficking.},
  author={Sylvain Gabriele and A M Benoliel and Pierre Bongrand and Olivier Th{\'e}odoly},
  journal={Biophysical journal},
  year={2009},
  volume={96 10},
  pages={4308-18}
}
Circulating leukocyte sequestration in pulmonary capillaries is arguably the initiating event of lung injury in acute respiratory distress syndrome. We present a microfluidic investigation of the roles of actin organization and myosin II activity during the different stages of leukocyte trafficking through narrow capillaries (entry, transit and shape relaxation) using specific drugs (latrunculin A, jasplakinolide, and blebbistatin). The deformation rate during entry reveals that cell stiffness… CONTINUE READING
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