Microfluidic force spectroscopy for characterization of biomolecular interactions with piconewton resolution.

Abstract

In this paper we present a scalable method based on the use of microfluidics and shear force spectroscopy which can be used for determining the affinity between molecules. Our method involves the use of functionalization of the surface of microfluidic channels with ligand molecules, and the surface of microspheres with receptor molecules. Bound beads are… (More)

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