Microfluidic fabrication of monodisperse biocompatible and biodegradable polymersomes with controlled permeability.

@article{Shum2008MicrofluidicFO,
  title={Microfluidic fabrication of monodisperse biocompatible and biodegradable polymersomes with controlled permeability.},
  author={Ho Cheung Shum and Jin-Woong Kim and David A Weitz},
  journal={Journal of the American Chemical Society},
  year={2008},
  volume={130 29},
  pages={9543-9}
}
We describe a versatile technique for fabricating monodisperse polymersomes with biocompatible and biodegradable diblock copolymers for efficient encapsulation of actives. We use double emulsion as a template for the assembly of amphiphilic diblock copolymers into vesicle structures. These polymersomes can be used to encapsulate small hydrophilic solutes. When triggered by an osmotic shock, the polymersomes break and release the solutes, providing a simple and effective release mechanism. The… CONTINUE READING