Microfluidic endothelial cell culture model to replicate disturbed flow conditions seen in atherosclerosis susceptible regions.

@article{Estrada2011MicrofluidicEC,
  title={Microfluidic endothelial cell culture model to replicate disturbed flow conditions seen in atherosclerosis susceptible regions.},
  author={Rosendo Estrada and Guruprasad Giridharan and Mai-Dung T Nguyen and Sumanth D. Prabhu and Palaniappan Sethu},
  journal={Biomicrofluidics},
  year={2011},
  volume={5 3},
  pages={32006-3200611}
}
Atherosclerotic lesions occur non-randomly at vascular niches in bends and bifurcations where fluid flow can be characterized as "disturbed" (low shear stress with both forward and retrograde flow). Endothelial cells (ECs) at these locations experience significantly lower average shear stress without change in the levels of pressure or strain, which affects the local balance in mechanical stresses. Common in vitro models of atherosclerosis focus primarily on shear stress without accounting for… CONTINUE READING
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