Microfluidic device to study arterial shear-mediated platelet-surface interactions in whole blood: reduced sample volumes and well-characterised protein surfaces.

@article{Kent2010MicrofluidicDT,
  title={Microfluidic device to study arterial shear-mediated platelet-surface interactions in whole blood: reduced sample volumes and well-characterised protein surfaces.},
  author={Nigel J. Kent and Lourdes Basabe-Desmonts and Gerardene Meade and Brian D. MacCraith and Brian G. Corcoran and Dermot Kenny and Antonio J. Ricco},
  journal={Biomedical microdevices},
  year={2010},
  volume={12 6},
  pages={987-1000}
}
We report a novel device to analyze cell-surface interactions under controlled fluid-shear conditions on well-characterised protein surfaces. Its performance is demonstrated by studying platelets interacting with immobilised von Willebrand Factor at arterial vascular shear rates using just 200 μL of whole human blood per assay. The device's parallel-plate flow chamber, with 0.1 mm² cross sectional area and height-to-width ratio of 1:40, provides uniform, well-defined shear rates along the chip… CONTINUE READING
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