Microfluidic device reads up to four consecutive base pairs in DNA sequencing-by-synthesis.

@article{Kartalov2004MicrofluidicDR,
  title={Microfluidic device reads up to four consecutive base pairs in DNA sequencing-by-synthesis.},
  author={Emil P. Kartalov and Stephen R Quake},
  journal={Nucleic acids research},
  year={2004},
  volume={32 9},
  pages={2873-9}
}
We have developed the first fully integrated microfluidic system for DNA sequencing-by-synthesis. Using this chip and fluorescence detection, we have reliably sequenced up to 4 consecutive bps. The described sequencer can be integrated with other microfluidic components on the same chip to produce true lab-on-a-chip technology. The surface chemistry that was designed to anchor the DNA to elastomeric microchannels is useful in a broad range of studies and applications. 

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