Microfluidic chip system for the selection and enrichment of cell binding aptamers.

@article{Stoll2015MicrofluidicCS,
  title={Microfluidic chip system for the selection and enrichment of cell binding aptamers.},
  author={Heidi Stoll and Heiko Kiessling and Martin Stelzle and Hans Peter Wendel and Julia Schuette and Britta Hagmeyer and Meltem Avci-Adali},
  journal={Biomicrofluidics},
  year={2015},
  volume={9 3},
  pages={
          034111
        }
}
Aptamers are promising cell targeting ligands for several applications such as for the diagnosis, therapy, and drug delivery. Especially, in the field of regenerative medicine, stem cell specific aptamers have an enormous potential. Using the combinatorial chemistry process SELEX (Systematic Evolution of Ligands by Exponential enrichment), aptamers are selected from a huge oligonucleotide library consisting of approximately 10(15) different oligonucleotides. Here, we developed a microfluidic… CONTINUE READING