Microfluidic analysis of extracellular matrix-bFGF crosstalk on primary human myoblast chemoproliferation, chemokinesis, and chemotaxis.

@article{Ferreira2015MicrofluidicAO,
  title={Microfluidic analysis of extracellular matrix-bFGF crosstalk on primary human myoblast chemoproliferation, chemokinesis, and chemotaxis.},
  author={Meghaan M Ferreira and Ruby E. Dewi and Sarah C Heilshorn},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2015},
  volume={7 5},
  pages={569-79}
}
Exposing myoblasts to basic fibroblast growth factor (bFGF), which is released after muscle injury, results in receptor phosphorylation, faster migration, and increased proliferation. These effects occur on time scales that extend across three orders of magnitude (10(0)-10(3) minutes). Finite element modeling of Transwell assays, which are traditionally used to assess chemotaxis, revealed that the bFGF gradient formed across the membrane pore is short-lived and diminishes 45% within the first… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS
8 Citations
40 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Downloaded on 01/05/2015 19:53:56. This article is licensed under a Creative Commons Attribution-NonCommercial 3

  • Integrative Biology Paper Open Access Article…
  • 2015

Downloaded on 01/05/2015 19:53:56. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence

  • Paper Integrative Biology Open Access Article
  • 2015

Small

  • H Romano, K J Lampe, H Xu, M M Ferreira, S C Heilshorn
  • Small
  • 2015

Integr. Biol

  • A Shamloo, M Manchandia, +5 authors S Heilshorn
  • Integr. Biol
  • 2013

Med. Sci

  • S Mori, Y Takada
  • Med. Sci
  • 2013

Mutat. Res., Rev. Mutat. Res

  • A Kramer, C Walzl, +4 authors Dolznig
  • Mutat. Res., Rev. Mutat. Res
  • 2013

Methods Enzymol

  • O Meijering, I Dzyubachyk, Smal
  • Methods Enzymol
  • 2012

Cold Spring Harbor Perspect. Biol

  • A Huttenlocher, A R Horwitz
  • Cold Spring Harbor Perspect. Biol
  • 2011

Lab Chip

  • A Shamloo, S C Heilshorn
  • Lab Chip
  • 2010

BJU Int

  • A Yanagiuchi, H Miyake, M Nomi, A Takenaka, M Fujisawa
  • BJU Int
  • 2009

Similar Papers

Loading similar papers…