Microfluidic Single-Cell Analysis Shows That Porcine Induced Pluripotent Stem Cell–Derived Endothelial Cells Improve Myocardial Function by Paracrine Activation

  title={Microfluidic Single-Cell Analysis Shows That Porcine Induced Pluripotent Stem Cell–Derived Endothelial Cells Improve Myocardial Function by Paracrine Activation},
  author={Mingxia Gu and Patricia K. Nguyen and Andrew Stephen Lee and Dan-ling Xu and Shijun Hu and Jordan R. Plews and Leng Han and Bruno C Huber and Won Hee Lee and Yongquan Gong and Patr{\'i}cia E. de Almeida and Jennifer K. Lyons and Fumiaki Ikeno and Cholawat Pacharinsak and Andrew J. Connolly and Sanjiv Sam Gambhir and Robert C. Robbins and Michael T. Longaker and Joseph C. Wu},
  journal={Circulation Research},
Rationale: Induced pluripotent stem cells (iPSCs) hold great promise for the development of patient-specific therapies for cardiovascular disease. However, clinical translation will require preclinical optimization and validation of large-animal iPSC models. Objective: To successfully derive endothelial cells from porcine iPSCs and demonstrate their potential utility for the treatment of myocardial ischemia. Methods and Results: Porcine adipose stromal cells were reprogrammed to generate… 

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