Microfabricated structures for integrated DNA analysis.

@article{Burns1996MicrofabricatedSF,
  title={Microfabricated structures for integrated DNA analysis.},
  author={Mark A. Burns and Carlos H. Mastrangelo and Timothy S. Sammarco and Feng Man and James R. Webster and B N Johnsons and Bradley Foerster and Darren Jones and Y Fields and Adam R. Kaiser and David T Burke},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 11},
  pages={
          5556-61
        }
}
Photolithographic micromachining of silicon is a candidate technology for the construction of high-throughput DNA analysis devices. However, the development of complex silicon microfabricated systems has been hindered in part by the lack of a simple, versatile pumping method for integrating individual components. Here we describe a surface-tension-based pump able to move discrete nanoliter drops through enclosed channels using only local heating. This thermocapillary pump can accurately mix… CONTINUE READING

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