Microfabricated collagen tracks facilitate single cell metastatic invasion in 3D.

@article{KraningRush2013MicrofabricatedCT,
  title={Microfabricated collagen tracks facilitate single cell metastatic invasion in 3D.},
  author={Casey M. Kraning-Rush and Shawn P. Carey and Marsha C Lampi and Cynthia A. Reinhart-King},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2013},
  volume={5 3},
  pages={606-16}
}
While the mechanisms employed by metastatic cancer cells to migrate remain poorly understood, it has been widely accepted that metastatic cancer cells can invade the tumor stroma by degrading the extracellular matrix (ECM) with matrix metalloproteinases (MMPs). Although MMP inhibitors showed early promise in preventing metastasis in animal models, they have largely failed clinically. Recently, studies have shown that some cancer cells can use proteolysis to mechanically rearrange their ECM to… CONTINUE READING
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