Microfabricated arrays for splitting and assay of clonal colonies.

  title={Microfabricated arrays for splitting and assay of clonal colonies.},
  author={Philip Charles Gach and Wei Xu and Samantha J King and Christopher E. Sims and James E Bear and Nancy L Allbritton},
  journal={Analytical chemistry},
  volume={84 24},
A microfabricated platform was developed for highly parallel and efficient colony picking, splitting, and clone identification. A pallet array provided patterned cell colonies which mated to a second printing array composed of bridging microstructures formed by a supporting base and attached post. The posts enabled mammalian cells from colonies initially cultured on the pallet array to migrate to corresponding sites on the printing array. Separation of the arrays simultaneously split the… CONTINUE READING

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