Microfabricated airflow nozzle for microencapsulation of living cells into 150 micrometer microcapsules.

@article{Sugiura2007MicrofabricatedAN,
  title={Microfabricated airflow nozzle for microencapsulation of living cells into 150 micrometer microcapsules.},
  author={Shinji Sugiura and Tatsuya Oda and Yasuyuki Aoyagi and Ryota Matsuo and Tsuyoshi Enomoto and Kunio Matsumoto and Toshikazu Nakamura and Mitsuo Satake and Atsushi Ochiai and Nobuhiro Ohkohchi and Mitsutoshi Nakajima},
  journal={Biomedical microdevices},
  year={2007},
  volume={9 1},
  pages={91-9}
}
Microencapsulation of genetically engineered cells has attracted much attention as an alternative nonviral strategy to gene therapy. Though smaller microcapsules (i.e. less than 300 microm) theoretically have various advantages, technical limitations made it difficult to prove this notion. We have developed a novel microfabricated device, namely a micro-airflow-nozzle (MAN), to produce 100 to 300 microm alginate microcapsules with a narrow size distribution. The MAN is composed of a nozzle with… CONTINUE READING

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