Microfabricated Physical Spatial Gradients for Investigating Cell Migration and Invasion Dynamics

@inproceedings{Mak2011MicrofabricatedPS,
  title={Microfabricated Physical Spatial Gradients for Investigating Cell Migration and Invasion Dynamics},
  author={Michael Mak and Cynthia A. Reinhart-King and David Erickson},
  booktitle={PloS one},
  year={2011}
}
We devise a novel assay that introduces micro-architectures into highly confining microchannels to probe the decision making processes of migrating cells. The conditions are meant to mimic the tight spaces in the physiological environment that cancer cells encounter during metastasis within the matrix dense stroma and during intravasation and extravasation through the vascular wall. In this study we use the assay to investigate the relative probabilities of a cell 1) permeating and 2… CONTINUE READING