Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes.

@article{Bissell2005MicroenvironmentalRO,
  title={Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes.},
  author={Mina J. Bissell and Paraic A. Kenny and Derek C. Radisky},
  journal={Cold Spring Harbor symposia on quantitative biology},
  year={2005},
  volume={70},
  pages={343-56}
}
It is now widely accepted that elements of the cellular and tissue microenvironment are crucial regulators of cell behavior in culture and homeostasis in vivo, and that many of the same factors influence the course of tumor progression. Less well established is the extent to which extracellular factors actually cause cancer, and the circumstances under which this may occur. Using physiologically relevant three-dimensional culture assays and transgenic animals, we have explored how the… CONTINUE READING

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