Microenvironmental effects limit efficacy of thymoquinone treatment in a mouse model of ovarian cancer

Abstract

Ovarian cancer is the most lethal gynecologic malignancy, with limited treatment options for chemoresistant disease. An important link between inflammation and peritoneal spread of ovarian cancer is NF-κB signaling. Thymoquinone (TQ) exerts multiple anti-tumorigenic cellular effects, including NF-κB inhibition. We aimed to investigate the therapeutic… (More)
DOI: 10.1186/s12943-015-0463-5

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