Microenvironmental adaptation of experimental tumours to chronic vs acute hypoxia

  title={Microenvironmental adaptation of experimental tumours to chronic vs acute hypoxia},
  author={Oliver Thews and Tanja Wolloscheck and Wolfgang Dillenburg and Stephan Kraus and Debra K. Kelleher and Moritz Anton Konerding and Peter Vaupel},
  journal={British Journal of Cancer},
  pages={1181 - 1189}
This study investigated long-term microenvironmental responses (oxygenation, perfusion, metabolic status, proliferation, vascular endothelial growth factor (VEGF) expression and vascularisation) to chronic hypoxia in experimental tumours. Experiments were performed using s.c.-implanted DS-sarcomas in rats. In order to induce more pronounced tumour hypoxia, one group of animals was housed in a hypoxic atmosphere (8% O2) for the whole period of tumour growth (chronic hypoxia). A second group was… CONTINUE READING


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