Microenvironment of ruptured cerebral aneurysms discovered using data driven analysis of gene expression

@article{Landry2019MicroenvironmentOR,
  title={Microenvironment of ruptured cerebral aneurysms discovered using data driven analysis of gene expression},
  author={A. Landry and M. Balas and J. Spears and Z. Zador},
  journal={PLoS ONE},
  year={2019},
  volume={14}
}
Background It is well known that ruptured intracranial aneurysms are associated with substantial morbidity and mortality, yet our understanding of the genetic mechanisms of rupture remains poor. We hypothesize that applying novel techniques to the genetic analysis of aneurysmal tissue will yield key rupture-associated mechanisms and novel drug candidates for the prevention of rupture. Methods We applied weighted gene co-expression networks (WGCNA) and population-specific gene expression… Expand

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