Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia.

@article{Gutjahr2018MicroenvironmentinducedCP,
  title={Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia.},
  author={Julia Christine Gutjahr and Eva Szenes and Lisa Tschech and Daniela Asslaber and Michaela Schlederer and S Roos and Xiaobing Yu and Tamara Girbl and Christina Sternberg and Alexander Egle and Fritz Aberger and Ronen Alon and Lukas Kenner and Richard Greil and V{\'e}ronique Orian-Rousseau and Tanja N Hartmann},
  journal={Blood},
  year={2018},
  volume={131 12},
  pages={1337-1349}
}
Chronic lymphocytic leukemia (CLL) outgrowth depends on signals from the microenvironment. We have previously found that in vitro reconstitution of this microenvironment induces specific variant isoforms of the adhesion molecule CD44, which confer human CLL with high affinity to hyaluronan (HA). Here, we determined the in vivo contribution of standard CD44… CONTINUE READING