Microenvironment complexity and matrix stiffness regulate breast cancer cell activity in a 3D in vitro model

@inproceedings{Cavo2016MicroenvironmentCA,
  title={Microenvironment complexity and matrix stiffness regulate breast cancer cell activity in a 3D in vitro model},
  author={Marta Cavo and Marco Fato and Leonardo Pe{\~n}uela and Francesco Beltrame and Roberto Raiteri and Silvia Scaglione},
  booktitle={Scientific reports},
  year={2016}
}
Three-dimensional (3D) cell cultures represent fundamental tools for the comprehension of cellular phenomena both in normal and in pathological conditions. In particular, mechanical and chemical stimuli play a relevant role on cell fate, cancer onset and malignant evolution. Here, we use mechanically-tuned alginate hydrogels to study the role of substrate elasticity on breast adenocarcinoma cell activity. The hydrogel elastic modulus (E) was measured via atomic force microscopy (AFM) and a… CONTINUE READING
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Atomic force microscopy to investigate spatial patterns of response to interleukin-1beta in engineered cartilage tissue elasticity

  • L Peñuela
  • Journal of biomechanics 47,
  • 2014

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