Microenvironment and Immunology Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment

Abstract

Natural killer (NK) cells are key innate immune effectors against multiple myeloma, their activity declining in multiple myeloma patients with disease progression. To identify the mechanisms underlying NK cell functional impairment, we characterized the distribution of functionally distinct NK cell subsets in the bone marrow of multiple myeloma-bearing mice… (More)

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@inproceedings{Ponzetta2015MicroenvironmentAI, title={Microenvironment and Immunology Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment}, author={Andrea Ponzetta and Giorgia Benigni and Fabrizio Antonangeli and Giuseppe Scium and Alessandra Zingoni and Maria Rosaria Ricciardi and Maria Teresa Petrucci and Angela Santoni and Giovanni Bernardini}, year={2015} }