Microenvironment and Immunology Glioblastoma Angiogenesis and Tumor Cell Invasiveness Are Differentially Regulated by b 8 Integrin

@inproceedings{Tchaicha2011MicroenvironmentAI,
  title={Microenvironment and Immunology Glioblastoma Angiogenesis and Tumor Cell Invasiveness Are Differentially Regulated by b 8 Integrin},
  author={Jeremy H. Tchaicha and Steve B. Reyes and Jaekyung Shin and Mohammad G. Hossain and Frederick F. Lang and Joseph H McCarty},
  year={2011}
}
Glioblastoma multiforme (GBM) is a highly invasive brain tumor that develops florid microvascular proliferation and hemorrhage. However, mechanisms that favor invasion versus angiogenesis in this setting remain largely uncharacterized. Here, we show that integrin b8 is an essential regulator of both GBM-induced angiogenesis and tumor cell invasiveness. Highly angiogenic and poorly invasive tumors expressed low levels of b8 integrin, whereas highly invasive tumors with limited neovascularization… CONTINUE READING
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A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis

  • JH Tchaicha, AK Mobley, MG Hossain, KD Aldape, JH. McCarty
  • Oncogene
  • 2010
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