Microenvironment and Immunology Chemotherapy Induces Intratumoral Expression of Chemokines in Cutaneous Melanoma , Favoring T-cell In fi ltration and Tumor Control

@inproceedings{Hong2011MicroenvironmentAI,
  title={Microenvironment and Immunology Chemotherapy Induces Intratumoral Expression of Chemokines in Cutaneous Melanoma , Favoring T-cell In fi ltration and Tumor Control},
  author={M. L. Hong and Anne-Laure Puaux and Caleb Huang and Laure Loumagne and Charlene Tow and Charles R Mackay and Masashi Kato and evost-Blondel and M Avril and Alessandra Nardin and J. -P. Abastado},
  year={2011}
}
T-cell infiltration is known to impact tumor growth and is associatedwith cancer patient survival. However, the molecular cues that favor T-cell infiltration remain largely undefined. Here, using a genetically engineeredmouse model of melanoma, we show that CXCR3 ligands and CCL5 synergize to attract effector T cells into cutaneous metastases, and their expression inhibits tumor growth. Treatment of tumor-bearing mice with chemotherapy induced intratumoral expression of these chemokines and… CONTINUE READING