Microenvironment and Immunology CCL2/CCR2-Dependent Recruitment of Functional Antigen- Presenting Cells into Tumors upon Chemotherapy


The therapeutic efficacy of anthracyclines relies, at least partially, on the induction of a dendritic cell– and T-lymphocyte–dependent anticancer immune response. Here, we show that anthracycline-based chemotherapy promotes the recruitment of functional CD11bþCD11cþLy6ChighLy6G MHCIIþ dendritic cell–like antigenpresenting cells (APC) into the tumor bed… (More)


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