Microenvironment and Immunology Augmenting Antitumor T-Cell Responses to Mimotope Vaccination by Boosting with Native Tumor Antigens

Abstract

Vaccination with antigens expressed by tumors is one strategy for stimulating enhanced T-cell responses against tumors. However, these peptide vaccines rarely result in efficient expansion of tumor-specific T cells or responses that protect against tumor growth. Mimotopes, or peptide mimics of tumor antigens, elicit increased numbers of T cells that… (More)

Topics

7 Figures and Tables

Cite this paper

@inproceedings{Buhrman2012MicroenvironmentAI, title={Microenvironment and Immunology Augmenting Antitumor T-Cell Responses to Mimotope Vaccination by Boosting with Native Tumor Antigens}, author={Jonathan D. Buhrman and Kimberly R Jordan and Lance U'ren and Jonathan Sprague and Charles B. Kemmler and Jill E. Slansky}, year={2012} }