Microenvironment Carcinoma Cell Survival and Interaction with the Adjacent Regulates Mammary β − Transforming Growth Factor

@inproceedings{Bierie2008MicroenvironmentCC,
  title={Microenvironment Carcinoma Cell Survival and Interaction with the Adjacent Regulates Mammary β − Transforming Growth Factor},
  author={Brian Bierie and Daniel G Stover and Ty William Abel and Anna Chytil and Agnieszka E. Gorska and Mary E. Aakre and Elizabeth Forrester and Li Yang and K Wagner and Harold L Moses},
  year={2008}
}
Transforming growth factor (TGF)–B signaling has been associated with early tumor suppression and late tumor progression; however, many of the mechanisms that mediate these processes are not known. Using Cre/LoxP technology, with the whey acidic protein promoter driving transgenic expression of Cre recombinase (WAP-Cre), we have now ablated the type II TGF-B receptor (TBRII) expression specifically within mouse mammary alveolar progenitors. Transgenic expression of the polyoma virus middle T… CONTINUE READING

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