Microencapsulation of erythromycin and clarithromycin using a spray-drying technique.

  title={Microencapsulation of erythromycin and clarithromycin using a spray-drying technique.},
  author={Slim Zgoulli and Vincent Grek and Guy Barre and Gerhard Goffinet and Philippe Thonart and Stephen H. Zinner},
  journal={Journal of microencapsulation},
  volume={16 5},
Previous methods of microencapsulation are unable to process particles smaller than 100 microm without organic solvents or the use of multistep processes. The present study investigates the feasiblity of a one-step spray-drying process to microencapsulate erythromycin and clarithromycin, antibiotics known to have an unpleasant, bitter taste. Mixtures of clarithromycin (5% by weight) or erythromycin (30% by weight) with a biodegradable polymer were prepared and spray-dried under specific… Expand
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