Microencapsulated human hair dermal papilla cells: a substitute for dermal papilla?

@article{Lin2008MicroencapsulatedHH,
  title={Microencapsulated human hair dermal papilla cells: a substitute for dermal papilla?},
  author={Changmin Lin and Y. Li and Ying-chang Ji and Huang Keng and Xiang-na Cai and Jin-kun Zhang},
  journal={Archives of Dermatological Research},
  year={2008},
  volume={300},
  pages={531-535}
}
Dermal papillae (DP) play a pivotal role in hair formation, growth and cycling. However, the number of DP is limited. In this study, we report the production of “reconstructed DP” by enclosing DP cells within an alginate–polylysine–alginate (APA) semipermeable membrane. MTT assay and electron microscopy showed that the microencapsulated dermal papilla cells retained normal activity. The microcapsules were implanted into rat footpads, which lack follicles and sebaceous glands, to assess their… 
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References

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TLDR
It is demonstrated for the first time that papilla cells can be serially cultured for a long period without losing their hair-inductive potency and sustained the innate hair follicle inductive ability at a level comparable with that of intact dermal papillae.
Induction of hair growth in ear wounds by cultured dermal papilla cells.
TLDR
The results further illustrate that the inductive powers and developmental information retained by cultured dermal papilla cells parallel the properties of their embryonic precursors; the findings may have implications for human hair growth.
Whisker growth induced by implantation of cultured vibrissa dermal papilla cells in the adult rat.
TLDR
It is demonstrated that cultured papilla cells of early passage numbers retain their ability to induce hair growth, which appears to be an essential functional component of papilla cell activity which operates to regulate the profound morphogenetic changes that occur during the hair growth cycle.
The in vitro properties of dermal papilla cell lines established from human hair follicles
TLDR
In serial subcultures, the dermal papilla cells displayed a spread out, polygonal cellular morphology at stationary growth phases and a tendency to form multi‐layered aggregates before reaching confluence, compared with dermal fibroblasts which exhibited a shorter in vitro survival time.
Vibrissa dermal papilla cell aggregative behaviour in vivo and in vitro.
TLDR
The collective behaviour of the dermal papilla cells revealed in this study may be significant for the morphogenetic activity of the papilla, and for papilla size during the hair cycle, and may also reflect the retention of embryonic-like properties by the Dermal component of adult hair follicles.
Induction of follicle formation and hair growth by vibrissa dermal papillae implanted into rat ear wounds: vibrissa-type fibres are specified.
TLDR
Findings show that adult rat papillae retain the capacity, as displayed by embryonic dermis, to determine vibrissa specificity in induced follicles.
Hair follicle reformation induced by dermal papilla cells from human scalp skin
TLDR
Hair follicle-like structure reformation was found in dermal sheath cell-populated collagen gel when combined with superior or inferior epithelial cells, and Dermal papilla cells also induced superior and inferior epitocytes to form hair follicle on nude mice.
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TLDR
It has been suggested that the dermal papilla may be involved in both the induction of follicle lengthening and hair growth during the proanagen phase of the hair cycle, a concept now justified by direct experimentation in the vibrissa follicle at least.
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TLDR
This reconstitution model should be useful for identifying cell populations within the hair follicles compartment necessary for hair growth and for examining the effects of specific gene products on hair follicle growth and development in vivo.
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TLDR
The behaviour of human dermal papillae cells in culture is very similar to that reported in cultures of papilla cells from rat vibrissa follicles.
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