Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts.

@article{Silver1988MicroelectrodeSO,
  title={Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts.},
  author={Ian A Silver and Richard J. Murrills and David J. Etherington},
  journal={Experimental cell research},
  year={1988},
  volume={175 2},
  pages={
          266-76
        }
}
  • Ian A Silver, Richard J. Murrills, David J. Etherington
  • Published in Experimental cell research 1988
  • Biology, Medicine
  • Osteoclasts and activated macrophages in culture were shown to generate an acidic microenvironment specifically in the attachment zone between the cell and the base of the culture dish. Measurements using pH microelectrodes revealed that osteoclasts, when firmly attached, could achieve a pH fall of about 1 unit min-1 to a limit value of pH 3.0 or less. Activated macrophages produced a slower fall of 0.5-2 pH units h-1 and a limit value of pH 3.6-3.7 was generally detected. The method of… CONTINUE READING

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