Microelectrode determination of pH and PCO2 in rat proximal tubule after benzolamide: evidence for hydrogen ion secretion.

@article{Dubose1979MicroelectrodeDO,
  title={Microelectrode determination of pH and PCO2 in rat proximal tubule after benzolamide: evidence for hydrogen ion secretion.},
  author={Thomas D Dubose and L R Pucacco and Donald Wayne Seldin and Nicholle Carter and Juha P Kokko},
  journal={Kidney international},
  year={1979},
  volume={15 6},
  pages={624-9}
}
Previous micropuncture studies supporting hydrogen secretion as the mechanism of bicarbonate reabsorption have relied on the demonstration of an acid disequilibrium pH in the proximal tubule after systemic administration of a carbonic anhydrase inhibitor. Previous calculations of disequilibrium pH, however, have involved the necessary assumption that PCO2 in the proximal convoluted tubule was equal to arterial blood PCO2. This assumption can no longer be supported in view of the recent… CONTINUE READING

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