Microdrop screening: a rapid method to optimize solvent conditions for NMR spectroscopy of proteins.

@article{Lepre1998MicrodropSA,
  title={Microdrop screening: a rapid method to optimize solvent conditions for NMR spectroscopy of proteins.},
  author={Christopher A Lepre and Jonathan M. Moore},
  journal={Journal of biomolecular NMR},
  year={1998},
  volume={12 4},
  pages={493-9}
}
Determining appropriate solvent conditions is a crucial first step for carrying out NMR spectroscopy of proteins, but rapid and efficient methods for doing so are currently lacking. Microdrop screening examines a large number of different solvent conditions using very small amounts of protein and minimal labor. Starting from one initial buffer condition, small aliquots of protein solution are combined with an array of solutions in which concentration, pH, buffer type, and added stabilizers are… CONTINUE READING

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