Microdrilled cartilage defects treated with thrombin-solidified chitosan/blood implant regenerate a more hyaline, stable, and structurally integrated osteochondral unit compared to drilled controls.

@article{Marchand2012MicrodrilledCD,
  title={Microdrilled cartilage defects treated with thrombin-solidified chitosan/blood implant regenerate a more hyaline, stable, and structurally integrated osteochondral unit compared to drilled controls.},
  author={Catherine Marchand and Gaoping Chen and Nicolas Tran-Khanh and Jun Sun and Hongmei Chen and Michael D. Buschmann and Caroline D. Hoemann},
  journal={Tissue engineering. Part A},
  year={2012},
  volume={18 5-6},
  pages={508-19}
}
This study analyzed the long-term cartilage and subchondral bone repair of microdrilled defects treated with chitosan glycerol-phosphate/blood implant, using thrombin (Factor IIa) to accelerate in situ solidification. We also evaluated the cartilage repair response to six smaller microdrill holes compared with two larger holes. Bilateral knee trochlear cartilage defects were created in n=8 skeletally mature rabbits, drilled with six proximal 0.5 mm and two distal 0.9 mm holes, then covered with… CONTINUE READING
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