Microdosimetric model for the induction of cell killing through medium-borne signals.

@article{Stewart2006MicrodosimetricMF,
  title={Microdosimetric model for the induction of cell killing through medium-borne signals.},
  author={Robert D. Stewart and Ruwan K. Ratnayake and Kristofer Jennings},
  journal={Radiation research},
  year={2006},
  volume={165 4},
  pages={460-9}
}
Microbeam, medium-transfer and low-dose experiments have demonstrated that intercellular signals can initiate many of the same biological events and processes as direct exposure to ionizing radiation. These phenomena cast doubt on cell-autonomous modes of action and the linear, no-threshold carcinogenesis paradigm. To account for the effects of intercellular signals, new approaches are needed to relate dosimetric quantities to the emission and processing of signals by irradiated and… CONTINUE READING