Microdialysis of interstitial amino acids during spreading depression and anoxic depolarization in rat neocortex.

@article{Fabricius1993MicrodialysisOI,
  title={Microdialysis of interstitial amino acids during spreading depression and anoxic depolarization in rat neocortex.},
  author={Martin Ejler Fabricius and Leif H. Jensen and Martin Lauritzen},
  journal={Brain research},
  year={1993},
  volume={612 1-2},
  pages={61-9}
}
We have examined the effect of cortical spreading depression (SD) and anoxic depolarization (AD) on the interstitial concentration changes of amino acids (AA) in the neocortex of anesthetized rats using microdialysis and HPLC. Accompanying SD alanine increased to 126 +/- 11%, arginine to 116 +/- 3%, aspartate to 160 +/- 17%, glutamate to 163 +/- 9%, glycine to 158 +/- 21%, serine to 125 +/- 9%, and taurine to 172 +/- 15% (mean +/- 1 S.E.M.). The increases lasted for about 1 min. Histidine… CONTINUE READING
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