Microdialysis in the study of extracellular levels of amino acids in the rat brain.

@article{Tossman1986MicrodialysisIT,
  title={Microdialysis in the study of extracellular levels of amino acids in the rat brain.},
  author={Ulf Tossman and Urban Ungerstedt},
  journal={Acta physiologica Scandinavica},
  year={1986},
  volume={128 1},
  pages={9-14}
}
Microdialysis has been used for in vivo studies of extracellular amino acids in rat brain. We describe a method where a probe was designed to be implanted vertically. This probe is suitable for regional stereotaxic studies of the rat brain. The dialysis probe was perfused with Ringer's solution and the perfusates were analysed for their amino acid content with a high performance liquid chromatography (HPLC) technique. An orthophthaldialdehyde derivative of the amino acids was formed before the… CONTINUE READING

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