Microdialysis combined with a sensitive radioimmunoassay. A technique for studying in vivo release of neuropeptides.

@article{Lindefors1987MicrodialysisCW,
  title={Microdialysis combined with a sensitive radioimmunoassay. A technique for studying in vivo release of neuropeptides.},
  author={Nils Lindefors and Ernst Brodin and Urban Ungerstedt},
  journal={Journal of pharmacological methods},
  year={1987},
  volume={17 4},
  pages={
          305-12
        }
}
Microdialysis in combination with radioimmunoassay was used to study in vivo release of neuropeptides in the rat brain. Microdialysis is a novel brain perfusion technique, by which molecules in the extracellular space may be monitored. This study describes the application to neuropeptide research. A radioimmunoassay procedure was adapted so that substance P- and neurokinin A-like immunoreactivity could be measured in samples collected during in vivo release experiments. The detection limits of… CONTINUE READING
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