Microdialysis Calibration Using Retrodialysis and Zero-Net Flux: Application to a Study of the Distribution of Zidovudine to Rabbit Cerebrospinal Fluid and Thalamus

@article{Wang1993MicrodialysisCU,
  title={Microdialysis Calibration Using Retrodialysis and Zero-Net Flux: Application to a Study of the Distribution of Zidovudine to Rabbit Cerebrospinal Fluid and Thalamus},
  author={Yanfeng Wang and Shekman L. Wong and Ronald J. Sawchuk},
  journal={Pharmaceutical Research},
  year={1993},
  volume={10},
  pages={1411-1419}
}
A retrodialysis (RD) method for the real-time calibration of on-line microdialysis (MD) procedures was investigated in vitro and in vivo. Calibration by retrodialysis was simultaneously validated through the use of a zero-net flux (ZNF) method, which assumes directional independence of diffusion of the solute. In RD, a calibrator with dialysance (PeA; effective permeability–surface area product) similar to that of the compound of interest is introduced into the perfusate. If the calibrator is… CONTINUE READING
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