Microdevice integrating innate and adaptive immune responses associated with antigen presentation by dendritic cells.

@article{Mitra2013MicrodeviceII,
  title={Microdevice integrating innate and adaptive immune responses associated with antigen presentation by dendritic cells.},
  author={Bhaskar Mitra and Rohit Jindal and Serom Lee and Dave Xu Dong and Lulu Li and N. S. Prabhath Sharma and Tim J. Maguire and Rene S. Schloss and Martin L. Yarmush},
  journal={RSC advances},
  year={2013},
  volume={3 36},
  pages={16002-16010}
}
Dendritic cells are the principal antigen presenting cells that are responsible for acquiring and transporting antigen from the peripheral tissue to the secondary lymphoid tissue. There they present it to T cells which ultimately initiate an antigen specific immune response. In vivo, the migration of dendritic cells (DCs) and T cell activation are intimately linked. However, ex vivo systems that facilitate integrated evaluation of DC chemotaxis and resulting T cell activation by migrated DCs… CONTINUE READING