Microdamage induced by in vivo Reference Point Indentation in mice is repaired by osteocyte-apoptosis mediated remodeling.

@article{Kennedy2017MicrodamageIB,
  title={Microdamage induced by in vivo Reference Point Indentation in mice is repaired by osteocyte-apoptosis mediated remodeling.},
  author={Oran D. Kennedy and Matin S. Lendhey and Peter Mauer and Anaya Philip and Jelena Basta-Pljakic and Mitchell B. Schaffler},
  journal={Bone},
  year={2017},
  volume={95},
  pages={192-198}
}
Reference Point Indentation (RPI) is a technology that is designed to measure mechanical properties that relate to bone toughness, or its ability to resist crack growth, in vivo. Independent of the mechanical parameters generated by RPI, its ability to initiate and propagate microcracks in bone is itself an interesting issue. Microcracks have a crucial biological relevance in bone, are central to its ability to maintain homeostasis. In healthy tissues, a process of targeted remodeling routinely… CONTINUE READING
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