Microcystin-RR induces apoptosis in fish lymphocytes by generating reactive oxygen species and causing mitochondrial damage

@article{Zhang2007MicrocystinRRIA,
  title={Microcystin-RR induces apoptosis in fish lymphocytes by generating reactive oxygen species and causing mitochondrial damage},
  author={Hongmei Zhang and Junhong Zhang and Yonggang Chen and Yuxuan Zhu},
  journal={Fish Physiology and Biochemistry},
  year={2007},
  volume={34},
  pages={307-312}
}
Microcystin-RR (MCRR), a very widespread toxic microcystin in China, has previously been proved to induce sensitive apoptosis in Carassius auratus lymphocytes in vitro. This study focused on the role of intracellular Ca2+, mitochondrial membrane potential, reactive oxygen species, and intracellular ATP in the mechanism of MCRR-induced apoptotic toxicity to… CONTINUE READING