Microcystin-LR promotes melanoma cell invasion and enhances matrix metalloproteinase-2/-9 expression mediated by NF-κB activation.

@article{Zhang2012MicrocystinLRPM,
  title={Microcystin-LR promotes melanoma cell invasion and enhances matrix metalloproteinase-2/-9 expression mediated by NF-κB activation.},
  author={Xiaolin Zhang and Ziyi Fu and Zongyao Zhang and Chen Miao and Pengfei Xu and Ting Wang and Liuyan Yang and Shupei Cheng},
  journal={Environmental science & technology},
  year={2012},
  volume={46 20},
  pages={11319-26}
}
This study aimed to explore the molecular mechanisms behind the stimulation effects of microcystin-LR (a well-known cyanobacterial toxin produced in eutrophic lakes or reservoirs) on cancer cell invasion and matrix metalloproteinases (MMPs) expression. Boyden chamber assay showed that microcystin-LR exposure (>12.5 nM) evidently enhanced the invasion ability of the melanoma cells (MDA-MB-435). Tumor Metastasis PCR Array demonstrated that 24 h microcystin-LR treatment (25 nM) caused… CONTINUE READING
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