Microcystin-LR exhibits immunomodulatory role in mouse primary hepatocytes through activation of the NF-κB and MAPK signaling pathways.

@article{Zhang2013MicrocystinLREI,
  title={Microcystin-LR exhibits immunomodulatory role in mouse primary hepatocytes through activation of the NF-κB and MAPK signaling pathways.},
  author={Jianying Zhang and Jin Chen and Zongping Xia},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2013},
  volume={136 1},
  pages={86-96}
}
Microcystin-leucine-arginine (MCLR) is an environmental toxin from harmful algae, which has been linked to hepatotoxicity with high risks associated with liver disease. In this study, we explored the role of MCLR in NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways, which are important in regulating inflammatory and immune responses, in human hepatoma cell line HepG2 and primary mouse hepatocytes (PMHs). By in vitro cell-free and luciferase reporter systems, Western blotting… CONTINUE READING

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